Ajith Kumar G.1 , Prabhash R.2 , Rajeev D. S.3 , Baburaj C.4 , Sanjay Sahadevan5
BACKGROUND We wanted to determine the effect of concomitantly administered ondansetron on duration of post-operative analgesia of tramadol hydrochloride in patients undergoing gynaecological surgeries to compare the incidence of post-operative vomiting between Tramadol group and Tramadol-Ondansetron group. METHODS The study was approved by our Institutional Ethics Committee and all patients provided written informed consent. Sixty patients in the age group of 25 to 65 years belonging to ASA physical status I and II were induced in a prospective double-blind randomized study. All patients were scheduled for elective gynaecological surgeries under subarachnoid block. RESULTS The duration of analgesia in both groups was assessed with VAS pain score. Tramadol group had better mean duration of analgesia, 327 minutes than the concomitant group, 220 minutes. p value <0.001. CONCLUSIONS Post-operative use of Tramadol with ondansetron cannot be recommended, because ondansetron reduces the analgesic power of Tramadol.
