COMPARATIVE STUDY OF RAISE OF SERUM CREATINE PHOSPHOKINASE CONCENTRATION WITH DEPOLARIZING MUSCLE RELAXANT SUCCINYL CHOLINE AND NON-DEPOLARIZING MUSCLE RELAXANT VECURONIUM IN ASA GRADE-I PATIENT IN PAEDIATRIC AGE GROUP

Abstract

Venkateshwar Reddy P1, Raghavender M2

BACKGROUND
Neuromuscular blocking agents are classified as depolarising and non-depolarising agents. Each category of drug has its own advantages and along with them comes the side-effects. Selection of neuromuscular blocking agent therefore depends on their actions.
AIM OF STUDY
Present study is undertaken to compare the raise of serum creatine phosphokinase concentration with depolarising muscle relaxant (succinyl choline) and non-depolarizing muscle relaxant (vecuronium) in ASA grade 1 patients in paediatric age group undergoing minor surgeries (minimal or no muscle cutting)
MATERIALS AND METHODS
In the present study, 80 paediatric patients (aged between 1-12 years) were randomly selected into Group A and Group B with 40 patients in each. Group A received inj. succinylcholine 2mg/kg and Group B received inj. vecuronium 0.1mg/kg to facilitate intubation. Pre-operative and post-operative blood samples were collected and Serum creatine phosphokinase levels were recorded.
RESULTS
The rise in serum creatine phosphokinase was observed in both group A and group B. But, the rise in group A was statistically significant.
CONCLUSION
Group A recorded a significant rise in serum creatine phosphokinase and Group B although recorded a rise in the enzyme levels it was statistically insignificant. So, whenever possible an alternative drug for succinylcholine to facilitate endotracheal intubation has to be sought in paediatric age group.

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