Abstract

COMPARATIVE STUDY OF DIFFERENTIAL EXPRESSION OF CYCLIN-E IN NORMAL PLACENTA, HYDROPIC ABORTUS AND GESTATIONAL TROPHOBLASTIC DISEASE

Author(s): Rupa Das

Gestational Trophoblastic Disease (GTD) encompasses a heterogeneous group of lesions, characterised by proliferation of pregnancy associated trophoblastic tissue. According to WHO, GTD was classified into three subgroups, such as- Neoplasm, non-neoplastic lesions and molar pregnancies. Clinical presentation, prognosis and management of each subgroups varies from one another. So, it is necessary to perfectly identify each subgroup among themselves and from their non-GTD mimickers, which is difficult to achieve based on histopathology alone. So, we employed Immuno-Histochemical (IHC) staining for CyclinE, that complements the histological diagnosis and hence in proper management of cases