Abstract

COLLAGENOUS SPHERULES OF THE BREAST: A DIAGNOSTIC ENIGMA

Author(s): Amrit Kaur Kaler1, Manjunath Y. A2, Varaprasad B. M3

INTRODUCTION
Collagenous spherule (CS) is an enigmatic finding in a breast lesion involving the lobular acini and ductules and is defined with the presence of eosinophilic intraluminal collagen rich spherules measuring 20-100 microns in diameter, surrounded by flattened myoepithelial cells.1 It is an uncommon incidental finding in less than 1-2% of biopsies associated with various benign and malignant diseases occurring in isolation or multifocally.2 A major growing concern surrounding collagenous spherules is that it might be misinterpreted as atypical ductal hyperplasia (ADH), cribriform ductal carcinoma in situ (DCIS), cribriform carcinoma or adenoid cystic carcinoma of breast.
We present a case of mobile cystic mass of the breast reported as fibrocystic disease of the breast with focal areas showing adenosis and hyperplastic changes with multiple ducts displayed a peculiar change with the presence of extracellular concentric hyaline material present within the intraluminal space, diagnostic of collagenous spherules.

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