Kiran Kumar Bollepaka1, Srawanthi Ponnuru2
BACKGROUND AND INTRODUCTION
Breast carcinoma is the first among women of all races and Hispanic origin populations; most common carcinoma in women and account for 25% of all female cancers, which is more than twice the prevalence of cancer in women at any other site. Recent information suggests globally breast carcinoma is the second leading cause of cancer related death and is the most common cancer among women excluding the non-melanoma skin cancer. Estrogen and Progesterone play a central role in regulating growth kinetics of a variety of epithelial lining like in breast and endometrium and are powerful predictive markers in carcinoma of breast.
AIMS AND OBJECTIVES
To study the correlation between ER and PR status and patient characteristics like age of patient, menarche, menopause, parity, tumour size, lymph node status and tumour grade in carcinoma breast patient.
MATERIALS AND METHODS
Forty patients were included in this study who were admitted with breast carcinoma, the patient characteristics are correlated with ER and PR status studied by immunohistochemistry. This study was done over the period from October 2013 to September 2015.
Patients with both ER/PR positive are better differentiated, low grade, small sized tumours and with less chance of lymph node metastasis. Progesterone receptor negative status is associated with lymph node metastasis independent of other patient characteristics. Grade 3 and 4 tumours showed lower level of Estrogen and Progesterone receptors irrespective of age.
ER/PR positive group were better differentiated, showed better prognosis with hormonal therapy. They were less aggressive, low lymph node metastasis when compared with patients with either of the receptors negative or both the receptors negative. Hence immunohistochemistry is a must as it provides valuable prognostic, predictive and therapeutic information.