Clinical Profile and Outcome of Multiple Organ Dysfunction Syndrome (MODS) in a Tertiary Care Centre of Manipal, Karnataka

Author(s): Manthappa Marijayanth1, Ashok Horatti2, Varsha Tandure3, Suheil Dhanse4

To study the clinical profile and outcome of multiple organ dysfunction syndrome
(MODS) in previously healthy adult patients and to assess the correlation
between sequential organ failure assessment (SOFA) score at admission and
mortality in these patients.
This study was conducted at a tertiary care hospital attached to a medical
college of south India. This was a prospective observational study. All adult
patients presenting with multiple organ dysfunction syndrome between October
2010 and June 2012 were selected for the study. SOFA score was recorded for
all the patients at the time of admission. Patients were followed up till the time
of death or discharge.
In this study, majority of the cases were males and belonged to middle age
group. Epidemic diseases such as scrub typhus and leptospirosis were the most
common causes of MODS. Fever was the most common presenting symptom of
MODS. Majority of patients recovered. Higher SOFA score at admission is
associated with increased mortality, duration of hospital stay, requirement of
ventilatory support, haemodialysis, and central venous access.
Infectious diseases are responsible for most cases of MODS. Higher SOFA score
at admission is associated with increased morbidity and mortality. Majority of
people recover with appropriate treatment.