Carotid Intima Media Thickness (CIMT) in Metabolic Syndrome (MS) - A Case Control Study

Author(s): Sanidhya Sethia1 , Sourya Acharya2 , Samarth Shukla3 , Neema Acharya4 , Amol Andhale5 , Yash Gupte6 , Vidyashree Hulkoti7

BACKGROUND Ultrasonographic B-mode measurement of the thickness of wall of major arteries is now possible. We wanted to measure the Carotid Intima Media Thickness (CIMT) and assess its correlation in subjects of Metabolic Syndrome (MS). METHODS This is a case control study conducted among 200 participants in Acharya Vinoba Bhave Rural Tertiary Care Hospital in central India. 100 patients with metabolic syndrome and 100 without metabolic syndrome fulfilling the inclusion and exclusion criteria were included in the study. Anthropometric measurements including height, weight, waist circumference, and BMI were recorded. Blood pressure was measured by standard methods. CIMT was measured by B-mode ultrasound as per protocol. RESULTS Mean age of the subjects in metabolic syndrome group and non-metabolic syndrome group was 44.93 ± 15.34 and 37.72 ± 12.83 respectively. 85% of the individuals with metabolic syndrome were obese (BMI ≥ 25 Kg/M 2 ). Triglycerides levels were higher (>150 mg/dL) in 66% of metabolic syndrome subjects as compared to control group (10%). The mean CIMT in MS group was 0.81 ± 0.23 and in control group was (0.66 ± 0.13); the difference was statistically significant (p<0.005). CONCLUSIONS MS subjects have increased CIMT that predisposes them to future cardiovascular risk.