Abstract

ATTENUATION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION WITH INTRAVENOUS DEXMEDETOMIDINE- A CLINICAL STUDY

Author(s): Balasubramanyam V1, Sunku Prasad2, Talisetti Jamuna3

BACKGROUND
Laryngoscopic manipulation and endotracheal intubation are very painful stimuli capable of producing tachycardia, arrhythmia and hypertension. The aim of the study was to evaluate the efficacy of single premedication dose of I. V dexmedetomidine in attenuating pressor response to laryngoscopy & endotracheal intubation.
MATERIALS AND METHODS
This study was carried out at S.V. Medical College, Tirupati for one year period. The study was undertaken after obtaining ethical committee clearance as well as written informed consent from all patients. 60 patients in the age group 20-40 yrs. of either sex, belonging to ASA grade I and II scheduled for elective surgical procedures under General anaesthesia were included. 60 patients aged between 20 to 40 years belonging to ASA grade I & II were randomly divided into 2 groups, each group consists of 30 patients Group I (Saline group) 100 ml normal saline infused, Group II (Dexmedetomidine group) 1 mcg/kg in 100 ml normal saline infused over 15 min. The hemodynamic parameters were monitored from baseline upto 10 min after intubation.
RESULTS
Demographic data were analysed by student’s t test. Analysis of variance for repeated measures (ANOVA) was used to analyse changes over time. The statistical software SPSS version 16.0 was used for the analysis of the data and Microsoft Word and Excel have been used to generate graphs, tables etc. There was statistically significant difference (p<0.05) between dexmedetomidine and normal saline in heart rate, systolic, diastolic, mean arterial pressure at all time points after tracheal intubation with dexmedetomidine.
CONCLUSION
Dexmedetomidine in the dose of 1 μg/kg as IV infusion, given 15 minutes before induction can be used safely to attenuate the pressor response to laryngoscopy and intubation without significant side effects.