Jaya Jose 1 , Sajeevan K. C 2 , Pushpalatha M3 , Sujina C. M4 , Anupa Lucas
BACKGROUND Metabolic syndrome is an emerging threat in our population. Metabolic syndrome is characterised by central obesity, hypertriglyceridaemia, low HDL cholesterol, hyperglycaemia and hypertension. Serum uric acid level has been reported to be associated with various cardiovascular complications of metabolic syndrome. However, its direct relationship with metabolic syndrome remains controversial. Thus, we planned this study to find the association of serum uric acid with all the components of metabolic syndrome. MATERIALS AND METHODS The study was a comparative study conducted among patients attending obesity clinic in Thrissur from March 2014 to March 2015. 56 subjects with metabolic syndrome and 54 subjects without metabolic syndrome between the age group 25-65yrs. with BMI ≥25kg/m2 were included in the study. Fasting blood glucose, lipid profile and uric acid estimation were done by analysers in the Central Laboratory, Government Medical College, Thrissur. Data analysis was done using SPSS software. The tests were statistically significant, if ‘p’ value <0.05. RESULTS Metabolic syndrome was observed in 50.9% of obese patients in our study. The mean serum uric acid levels were 6.07±1.61 and 4.62±1.33 in metabolic and non-metabolic syndrome respectively and were found to be statistically significant. The association of mean uric acid levels with BMI, FBS and triglycerides were statistically significant. CONCLUSION A significant positive association of uric acid with body mass index, waist circumference, triglycerides and fasting blood glucose. The association of uric acid with various components of metabolic syndrome support that it might be taken as a marker for metabolic syndrome.
