Sudhir Kumar Verma, Vivek Kumar, Purshottam Singh Yadav, Nikhil Kumar P. Joge, Ravi Misra
Liver plays a vital role in lipid metabolism. Hence, it is not unusual to expect perturbance in lipid profile in patients with liver cirrhosis. We evaluated lipid profile in patients of cirrhosis of liver and correlated their levels with severity of liver dysfunction. We also evaluated lipid profile as prognostic marker in cirrhosis of liver.
MATERIALS AND METHODS
Cross-sectional observational study was conducted among 139 patients of cirrhosis of liver. Patient were classified according to severity of cirrhosis based on child pugh's classification and MELD scoring. Apart from routine tests prescribed in patients of cirrhosis of liver, fasting lipid profile (Total cholesterol, triglycerides, HDL-C, VLDL-C, LDL-C) were assessed.
Significant decrease in total Cholesterol, HDL-C, LDL-C, VLDL-C and triglyceride levels observed in enrolled patient as compared to reference range value. Total cholesterol, HDL-C and VLDL-C levels were inversely related to severity of liver disease as measured by Child Pugh and MELD score. The decline in total cholesterol, HDL-C & VLDL-C was much greater in HCV related cirrhosis as compared to other aetiologies of cirrhosis.
Serum total cholesterol, HDL-C, VLDL-C can be used to assess the disease severity in patients with cirrhosis of liver and to predict the disease outcome. Screening for dyslipidaemia may be an important tool to initiate appropriate therapy to prevent adverse cardiovascular events in patients of cirrhosis of liver.