Venuturumilli Lakshmi Kameswari1, Venuturumilli Ravi Sankar2, Souris Kondaveti3
In the present study the anti-inflammatory activity of Alpinia galanga is evaluated using rat paw edema, in comparison with Indomethacin using digital Plethysmometer. Male Wistar rats were grouped into 3 of 6 each. Test group given 250mg/kg Alpinia galanga suspended in 2% gum acacia, Standard group 20mg/kg Indomethacin orally. Hind paw edema was produced by sub plantar injection of 0.1ml of 1% carrageenin and the paw edema was measured at 0 and 3 hrs after injection using digital plethysmometer. Mean increase in paw volume and percentage inhibition were calculated. Data were represented as percentage inhibition of paw volume and Mean±S.E.M. Statistical analysis was done using student ‘t’ test. P values < 0.05 were considered significant.
CONCLUSION: Alpinia galanga showed a 52.5% percentage of inhibition in comparison with Indomethacin which showed 68.75%. The test compound Alpinia galanga showed anti-inflammatory activity with a p value of <0.05 in comparison with Indomethacin with a p value of <0.001.