Author(s): Mohammed Umar Farooque1, Bharat Bhushan2
Blood haemoglobin (Hb) concentration serves as the key indicator for anaemia, because it can be measured directly.
Aim: To determine the profile of anaemia and to correlate the severity of anaemia with serum creatinine levels in pre- and post-dialysis CKD patients.
MATERIALS AND METHODS
The study was carried out over a period of 6 months. The study consisted of 40 pre- and post-dialysis CKD patients. Venous blood samples were obtained from patients before dialysis and after completion of dialysis. Hb, Hct and Red cell indices were calculated, peripheral blood smears were studied for red blood cell morphology and serum creatinine levels.
Of the 40 CKD patients, 20 (50%) were male and 20 (50%) were female. The age of the patients ranged from 20 - 83 years with mean age being 46.1 ± 1754 years. The most frequent causes of CKD was hypertension 30 (75%). Normocytic and normochromic anaemia was predominant in both pre- and post-dialysis patients. In post-dialysis patients, microcytic hypochromic and macrocytic normochromic anaemia was higher than in pre-dialysis patients (20% and 7.5%, respectively). Severe anaemia is increased in post-dialysis patients, i.e. 20% in pre-dialysis it is 5%. There was a significant difference in the Hb and Hct levels between post-dialysis and pre-dialysis patients (P < 0.001). The prevalence of anaemia was 100% in both pre- and post-dialysis patients. The relationship between Hb and Serum creatinine levels was determined using linear regression and correlation. The correlation between Hb and SC levels was not significant in both the pre- and post-dialysis groups (P > 0.05).
The most frequent anaemia in chronic kidney disease patients was normocytic and normochromic type of a moderate degree. Significant correlation was not found between the severity of anaemia and serum creatinine levels in both pre- and post-dialysis group of patients.