Abstract

AN ASSOCIATION BETWEEN THYROID FUNCTION STATUS AND BONE MINERAL DENSITY (BMD) AMONG POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS

Author(s): K. P. Neethu1, Santhosh Kumar SS2, Mini Joseph3

BACKGROUND
Osteoporosis is the most common metabolic bone disorder. It is a disorder characterized by low bone and micro architectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. Thyroid hormones are necessary to normal development and function of human skeleton.
The aim of this study was to investigate the association between thyroid function status and mineral density (BMD) among postmenopausal women with osteoporosis.
MATERIALS AND METHODS
The study was completed in central diagnostic biochemistry laboratory, medical college, Thiruvananthapuram. Consecutive blood samples (5 ml) were collected from the postmenopausal women after confirming menopause, attending camp under the guidance of orthopaedic department, MCH hospital, to detect Bone mineral density by quantitative ultra sonometry. Thiruvananthapuram and the parameters evaluating are Serum T3, T4, TSH, Serum Calcium, Phosphorous and ALP, in the Central Diagnostic Biochemistry Laboratory, Medical College Hospital, Thiruvananthapuram.
RESULTS
Average TSH of osteoporosis 1.61 ± 1.24, that of control 3.38 ± 1.65, p value is <0.001. There is a positive correlation between BMD and TSH, p value is Significant (<0.001) and r value (0.565). Average T4 of osteoporosis (10.54 ± 1.70), that of control (9.98 ± 1.67). and average T3 of osteoporosis (1.23 ± 0.25), that of control 1.13 ± 0.16. p value is >0.05. T3 and T4 shows No correlation with bone mineral density.
CONCLUSION
In osteoporosis population 83.3% of individuals having TSH value in the lower range of normal value. The study concluded that there is a positive correlation with Bone mineral density and TSH, even at TSH level with in the normal limit. The p value obtained is< 0.001 and the coefficient of correlation r = 0.565 Similarly, the study also concluded that there is no correlation of bone mineral density with T3 and T4. The mean serum levels of T3 and T4 were similar among women with or without osteoporosis. The low-normal TSH levels were associated with lowered BMD value. Average TSH of osteoporosis is 1.61 ± 1.24, that of control 3.38 ± 1.65, p value is <0.001
KEYWORDS
Bone Mineral Density, Osteoporosis, T3, T4, TSH.