BACKGROUND Oculomotor nerve palsies may present in one of four ways. 1) An isolated partial or complete nerve palsies without any other neurologic signs and symptoms except those related to the palsy itself. 2) In association with symptoms other than those related to the palsy (pain, dysesthesia, paraesthesia), but without any signs of neurologic (or) systemic disease. 3) In association with other ocular motor nerve palsies, but without any other neurologic signs. 4) In association with neurologic signs other than the oculomotor nerve palsy. MATERIALS AND METHODS The present study was conducted in Ophthalmic OPD of Government Medical College & Hospital, Anantapur, Andhra Pradesh. 80 cases were examined by proper history taking, complete neurological examination by neurologist and ocular examination to include and exclude the cases properly and the study period was from Feb. 2013 to Jan 2017. All patients having infranuclear neurologic lesion of third cranial nerve who attended the Ophthalmology OPD were included in the study after taking an informed consent. RESULTS Of them, 10% of the cases are due to undetermined causes, 8.75% of the cases are due to head trauma, 10% of the cases are due to neoplasms, 56.25% of the cases are due to vascular pathologies (diabetes mellitus, hypertension, etc.), 2.5% of the cases are due to aneurysms, 12.5% of the cases are due to nonspecific neuritis and 2.5% of the cases are due to various other pathologies. CONCLUSION Of all the causes, vascular pathologies are the most common causes followed by post inflammatory causes due to head trauma and undetermined causes.