Abstract

A STUDY ON SERUM FIBRINOGEN AS AN INDEPENDENT PREDICTOR OF MAJOR ADVERSE CARDIAC EVENTS IN KNOWN DIABETIC CORONARY ARTERY DISEASE PATIENTS

Author(s): M. Amudhan, A. Magesh, V. P. Kannan

BACKGROUND Diabetes mellitus is one of the leading cause of morbidity and mortality worldwide. It is an important risk factor in the pathogenesis of Acute Coronary Syndrome. Fibrinogen, being an acute phase reactant is also a procoagulant. Hence its role in adverse cardiac events in diabetics and its prognostic value is currently the study of interest. Aims and Objectives- 1. To determine the concentration of fibrinogen in Diabetic CAD patients. 2. To ascertain the prognostic value of serum fibrinogen in Diabetic patients. 3. To evaluate the relation between serum fibrinogen and other factors that cause adverse cardiac events. MATERIALS AND METHODS This study we are undertaking is a cross sectional study conducted in Thanjavur Medical College, Thanjavur. The study population includes 50 patients with diabetes mellitus admitted in department of internal medicine with past history of CAD or with evidence of CAD. The study period is from June 2016 to December 2016 for a period of 6 months. Department of cardiology and biochemistry are the collaborating departments in this study. RESULTS 52% of the patients in this study suffered from MACE. MACE is more common among older patients. Mean serum fibrinogen levels was significantly higher in patients with longer duration of diabetes and poor glycaemic control. Serum fibrinogen plays an important role in the pathogenesis of vascular complications in diabetics. There is a positive correlation between major adverse cardiac events and fibrinogen levels. CONCLUSION The study concludes that 52% of the patients suffered from MACE and there is no gender variation. MACE is more common among older patients. Longer the duration of diabetes and poor glycaemic control leads to severe MACE. Mean serum fibrinogen level has positive correlation with diabetic status of the patients. Increased serum fibrinogen level is associated with severity of MACE.