Hayatkhan Sikkandar Basha1, Chelliah Dharmaraj2
BACKGROUND
Overt diabetes mellitus (diabetes mellitus) and impaired glucose tolerance test has been reported 21%-30% and 60-80% respectively in patients with liver cirrhosis.1 The aim of the study is to assess the prevalence of impaired glucose tolerance among cirrhosis patients with normal blood sugar and to improve their long-term survival by early detection of impaired glucose tolerance by OGTT and timely institution of treatment.
MATERIALS AND METHODS
This study was conducted among 100 cirrhosis patients attending Gastro Clinic at Government Rajaji Hospital, Madurai. Patients with overt diabetes, complication of cirrhosis such as bleeding manifestation, hepatic encephalopathy, spontaneous bacterial peritonitis and moderate-to-severe ascites were excluded from the study.
RESULTS
In our study, the frequency of glucose metabolism disorder was 64%, of which 46% were IGT and 18% were diabetes mellitus. Such a high incidence of latent glucose metabolism disorder in cirrhosis was revealed with the routine use of OGTT. This test should be recommended routinely for cirrhosis patients for early detection of glucose metabolism disorder.
CONCLUSION
In our study, the frequency of glucose metabolism disorder was 64% among 46% were IGT and 18% were diabetes mellitus. This 64% was revealed after OGTT, which indicates of high incidence of latent glucose metabolism disorder in cirrhosis.
