Kallol Bhattacharjee 1 , Dwijen Das 2 , Pranab Rabha 3 , Amit Kumar Kalwar 4 , Giridhar Kar 5 , Prithwiraj Bhattacharjee 6

ABSTRACT: INTRODUCTION: Chronic kidney disease is a worldwide public health problem. Chronic renal failure is defined by the National Kidney Foundation as either damage or a glomerular filtration rate less than 60ml/minute/1.73m2 of body surface area for more than 3 months. The primary cause of anemia in patients with chronic renal failure is insufficient production of erythropoietin by the diseased kidneys. As there is paucity of data regarding the haematological changes in chronic renal failure in this region, the present study was aimed to achieve the following objectives. AIMS AND OBJECTIVES: 1. To assess the various hematological changes in chronic renal failure. 2. To assess the correlation between hematological and biochemical parameters. MATERIALS AND METHODS: The present study was conducted in the department of Medicine, in a tertiary care hospital, Assam for one year. STUDY DESIGN: Hospital based, single centred observational study. All patients with features of chronic renal failure, who were admitted in medicine wards, were taken randomly for the study. RESULTS: The series included 100 cases of which the highest number 37% were in the age group of 51-60 years. Male preponderance was observed with males being 65% and females 35%. Generalized weakness and swelling were the commonest symptoms observed in 76% and 74% cases and pallor, hypertension, pedal edema, ascites and acidotic breathing on examination were found in 85%, 70%, 57%, 17% and 17% cases respectively. 72% patients had serum creatinine between 5.1 to 10 mg/dl. A negative co-relationship was observed between serum creatinine and hemoglogin. All cases had anemia of which 52% had hemoglobin between 7 to 10 gm/dl, 61% had normocytic normochronic anemia and 20% had absolute iron deficiency. Diabetes was the commonest etiology in 42%, followed by hypertension 35%, undiagnosed 12%, chronic glomerulonephritis 7%, polycystic kidney and obstructive nephropathy in 2% each respectively. CONCLUSION: Anemia is the commonest haematological manifestation with normocytic normochromic anemia being the commonest morphological type. Absolute iron deficiency was significantly associated with chronic renal failure. Diabetes and hypertension were the commonest etiological factors. The concentration of haemoglobin showed negative correlationship with serum creatinine which was statistically significant. HOW TO CITE THIS ARTICLE: Kallol Bhattacharjee, Dwijen Das, Pranab Rabha, Amit Kumar Kalwar, Giridhar Kar, Prithwiraj Bhattacharjee. “A Study on Hematological Profile In Patients of Chronic Renal Failure With Special Reference To Serum Iron Profile”. Journal of Evidence based Medicine and Healthcare; Volume 2, Issue 46, November 09, 2015; Page: 8212-8219, DOI: 10.18410/jebmh/2015/1107 INTRODUCTION: Chronic kidney disease (CKD) is a worldwide public health problem.[1] The hallmark of CKD is structural and /or functional damage of the glomeruli of the kidney, resulting in progressive decrease in glomerular filtration rate (GFR). There have been discrepancies worldwide regarding the definition, classification and laboratory testing of CKD resulting in lack of uniformity. In 2000, the National Kidney Foundation (NKF) and the Dialysis Outcome Quality Initiative (DOQI) advisory board approved the development of clinical practice guidelines to define the chronic kidney disease and to classify stages in the progression of kidney disease. Chronic kidney disease is defined by the National Kidney Foundation as either damage or a GFR less than 60 ml/minute/1.73 m2 of body surface area (BSA) for more than 3 months. DEFINITION CRITERIA: 1. Kidney damage more than 3 months as defined by structural or functional abnormalities of kidneys with or without decreased GFR, manifest by either. Submission 28-10-2015, Peer Review 29-10-2015, Acceptance 02-11-2015, Published 06-11-2015. Corresponding Author: Dr. Dwijen Das, Associate Professor, Department of Medicine, Silchar Medical College and Hospital, PO. Ghungoor, Cachar-788014, Assam. E-mail: drdwijendas@yahoo.co.in DOI: 10.18410/jebmh/2015/1107 KEYWORDS: Anemia, Ascites, Creatinine, Diabetes Mellitus, Edema, Erythropoieti