Dr. K. Sridhar Reddy

BACKGROUND Prostate cancer is becoming a significant international health problem. There is a significant variation in incidence of clinical prostate cancer worldwide. We wanted to study the incidence of carcinoma of the prostate, its clinical presentation and different histopathological patterns including rare variants. We also wanted to grade prostatic carcinoma by Gleason system and study the correlation of prostate specific antigen levels with carcinoma whenever possible. METHODS This prospective study was performed for a period of 3 years from April 2015 to May 2018. The specimens were collected from Government Medical College Hospital Kadapa, private hospitals and nursing homes in and around Kadapa. The material is collected in 10% formalin. Grossing of suprapubic prostatectomy specimen is done as follows- weight of specimen, shape, colour and consistency, presence of hyperplastic nodules, cyst, areas suspicious of carcinoma. RESULTS The results of present study showed that conventional adenocarcinoma was the most common type of prostate carcinoma constituting 88% of cases, 4% of cases were diagnosed as ductal adenocarcinoma, 2% as transitional cell carcinoma, mucin adenocarcinoma, signet ring cell carcinoma and small cell carcinoma. Among these patients 19% graded as score 4 of Gleason’s grading, system 4% as score 5, 10% as score 6, 18% as each score of 7 and 8, 21% as score 9 and 10% as score 10. The highest level of PSA seen is in signet ring cell carcinoma. CONCLUSIONS In the present study, conventional adenocarcinoma was the commonest type of prostatic carcinoma. Gleason’s score 8-10 of Gleason’s grading system was the commonest score of the patients with adenocarcinoma of prostate.