Abstract

A STUDY ON CORRELATION OF SERUM URIC ACID LEVELS WITH SPIROMETRIC PARAMETERS OF COPD PATIENTS- A HOSPITAL BASED CROSS SECTIONAL OBSERVATIONAL STUDY

Author(s): Dr. V. Vimalraj,

BACKGROUND Chronic Obstructive Pulmonary Disease (COPD) is an umbrella term used to describe a variety of clinical conditions with progressive lung diseases. So far there are few evidences that there is a positive relationship between oxidative stresses related biomarkers and pulmonary function.1 Uric acid has antioxidant property and anti-inflammatory role when present in high levels. In this study, we examined the association between spirometric measures and serum uric acid levels in clinically stable patients attending OPD. METHODS This was a single centre nonrandomised prospective cross-sectional observational study. The diagnosis and classification of COPD was based on assessment of airflow limitation by post bronchodilator spirometry in stable condition. Patients were classified based on GOLD criteria. Principle used in serum uric acid estimation was uricase method by auto analyser. RESULTS 70 subjects were enrolled in our study. There is a positive association of serum uric acid level with smoking with odds ratio of 1.0704. The mean serum uric acid level rises with worsening GOLD stages which is shown in our study is statistically significant (p<0.05). CONCLUSIONS There is a relation of serum uric acid and the progress of disease in the patients suffering from COPD. Results of the study have improved our understanding regarding role of serum uric acid in COPD in Indian Population.