Navin Chandra1, Suresh Kumar Sinha2, Rajesh Tiwary3
BACKGROUND
To study the efficacy and safety of intraoperative Mitomycin – C with trabeculectomy in management of Primary open angle glaucoma. To compare the results between trabeculectomy alone and trabeculectomy with intraoperative Mitomycin in terms of control of IOP, arrest of visual field loss, visual acuity and optic nerve head changes.
MATERIALS AND METHODS
The patients were selected from the outpatient department of Ophthalmology, Nalanda Medical College, Patna. In the present study 60 eyes of 45 patients having primary open angle glaucoma were selected from the patients of attending Ophthalmology outpatient department. In all cases trabeculectomy was done. Cases were divided into two groups, group A and B. In group A 30 eyes were selected randomly for trabeculectomy with intraoperative Mitomycin C In group B 30 eyes were selected randomly for Trabeculectomy alone. Both eyes were operated in 15 cases. Definition of efficacy: Complete effectiveness </= 21 mmHg. Qualified effectiveness: IOP </= 21 mmHg with single glaucoma medication. Qualified failure : IOP > 21 mmHg with or without glaucoma medication. Complete failure: When an eye requires a further glaucoma drainage operation.
RESULTS
At 3 months follow up overall success rate in study group was 100%. Complete success in 27(90%) cases, 3(10%) qualified. In control group complete success was 11(33%) and 7(23.44%) was qualified success.
CONCLUSION
From the present study with a very short follow up period it can be concluded that the use of intraoperative Mitomycin –C in trabeculectomy has a better pressure lowering effect than trabeculectomy alone and it improves the success rate in high risk cases of primary open angle glaucoma (p 0.02943 Chi – square test).
