Babu Rao Rentapalli1, Santhoshi Sammeta2, Sridhar V. Maddikunta3, Souris Kondaveti4, Margaret Viola5

Non-enzymatic free radical mediated oxidation of biological molecules, membranes and tissues is associated with a variety of pathological events such as cancer, aging and diabetes mellitus.[1] Increased oxidative stress is seen in both types of diabetes mellitus namely type 1 and type 2, irrespective of duration, complications and treatment. In diabetes mellitus, oxidative stress seems primarily due to both an increased plasma free radical concentration and a sharp decline in antioxidant defences.[1] Among the causes of enhanced free radical production, hyperglycemia and hyper insulinemia seem to play a major role,[2,3] Hyperglycemia is the more easily modifiable factor among the two and good glycemic control can reduce the oxidative stress. Controversy persists regarding the other possible mechanisms of increased oxidative stress in diabetes and whether oxidative stress normalizes with adequate metabolic control alone. The role of oxidative stress and diabetic complications has been extensively investigated. Oxidative stress has been suggested to be involved in the genesis of both macro and micro angiopathy[4,5] Prospective trials are now underway addressing the controversial issues of possible role of pharmacological antioxidants in preventing or at least delaying the onset of diabetic complications.