A Study of Fasting and Postprandial Lipid Profile among Patients with and without Diabetes Mellitus in a Tertiary Care Hospital - Kottayam, Kerala

Author(s): Sneha Varikkaatu Prasanna1, Prasantha Kumar Thankappan2

Type 2 diabetes mellitus (DM) is characterized by insulin resistance which is
associated with glucose intolerance, hypertension, dyslipidaemia, a procoagulant
state, and an increase in the microvascular and the macrovascular disease. The
high cardiovascular mortality which is associated with type 2 DM is due to a
prolonged, exaggerated, postprandial state. The abnormal lipid profile in the
postprandial state is more significant than the abnormal lipid profile in the fasting
state in causing atherosclerotic complications in type 2 diabetes. Very few studies
are available on the estimation of the postprandial lipid profile in type 2 diabetes
patients. The purpose of this study was to compare fasting and postprandial lipid
levels among patients with and without diabetes mellitus and find out the
correlation between duration of detection of diabetes mellitus and postprandial
lipid levels among patients with diabetes mellitus.
This is a cross sectional analytical study of a study population of 200 subjects
including in patients and out patients of wards and diabetic clinic of Government
Medical College, Kottayam from April 2017 to March 2018. Data was coded and
entered in Microsoft Excel and IBM Statistical Package for Social Sciences (SPSS
version 22) for statistical analysis.
Diabetic patients had impaired fasting and postprandial lipid profiles. Impairment
in postprandial lipid profile when compared to non-diabetics was statistically
significant. Duration of detection of diabetes and postprandial lipid levels showed
weak positive correlation.
The postprandial lipid profile in diabetes mellitus patients is significantly deranged
compared to fasting state and is an important factor in assessing their
cardiovascular risk. Hence, there is a need to stress on postprandial lipid profile
estimation in diabetic patients.