A PROSPECTIVE STUDY OF EFFECT OF NATEGLINIDE VERSUS NATEGLINIDE IN COMBINATION WITH METFORMIN ON GLYCAEMIC CONTROL AND DYSLIPIDAEMIA IN TYPE ?? 2 DIABETES MELLITUS PATIENTS IN COASTAL DISTRICT OF ANDHRA PRADESH

Abstract

R. Rajendra Prasad1, V. Some Sekhar2, K. S. R. Swami3

BACKGROUND
Diabetes mellitus is a clinical syndrome characterised by hyperglycaemia caused by absolute or relative deficiency of insulin. Persistent hyperglycaemia leads to both micro and macrovascular complication, so a treatment goal is recommended. To achieve that various drug either as monotherapy or in combination is used.
MATERIAL AND METHOD
Forty patients having type 2 diabetes mellitus were selected randomly, those who are taking nateglinide alone or metformin in combination with nateglinide. Patients were divided in to two groups, each group having 20 patients, group 1 were taking nateglinide 60 mg and group 2 were taking nateglinide 60 mg plus metformin 500 mg. Metabolic parameters that are FPG, PPPG, Fasting, C- Peptide, HDL level, TG Level, LDL level and serum cholesterol were studied before and at the end of the study that is 16 weeks.
RESULT
There was significant reduction in FPG and PPPG in both the groups having p value <.0001. Fasting C-peptide level change was more significant in group 2 than group 1, that is 19.0% and 14.86% respectively. Change in lipid profile was more in group 2 than group 1.
CONCLUSION
We conclude that nateglinide and its combination both have equal effect on glycaemic control, but reduction in fasting C-peptide level is more when nateglinide in combination with metformin.

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