Author(s): Jawahar Yallappa Kadam1

The bile is emulsifying and corrosive agent. The secretion of bile and pancreatic digestive enzymes are carried into duodenum through common opening by major duodenal papilla. When the bile and pancreatic enzymes are trapped by chance, inside the duct system of the pancreas they behave like two biotoxic agents to the insulin molecules and cells of the islets of Langerhans and initiate the process for diabetes. The major and minor duodenal papilla are the openings present at posteromedial aspect of the second part of the duodenum. In the supine position these openings become dependent part for the flowing acidic chyme. If these openings are weak and defective or the microparticle of the chyme may regurgitate inside the pancreas and induce immunological reaction with the islets of Langerhans. In long run, these events initiate the process for diabetes. The congenital anomalies of the pancreas, the biliary apparatus, the duodenum and heavy pressure on the pancreas by abdominal obesity may provoke an obstruction to the normal flow of the bile, the chyme, the enzyme and may get its infiltration inside the pancreas. These events may initiate the process for diabetes.
The experimental animals are dogs and human. It should carried out on a trial and error basis by the team of scientists with the ethical rules. Here, the experiment is done to search an innovative aetiological factor for the diabetes, inject few millilitres of chyme or bovine milk inside the defective, weak sphincter of Oddi through the endoscopic retrograde approach or by the higher artificial intra-abdominal pressure; created on second part of duodenum and its immunological reaction on islets of Langerhans for the injected material are studied.
The microinfiltration of these biotoxic elements inside the pancreas creates antigenic reaction and stimulates type 1 and type 2 diabetes.
The defective, weak sphincter of Oddi in supine position becomes one of the aetiological factor. After long time, the weak sphincter allows the microinfiltration of chyme in reverse direction inside the pancreas and initiates a process for idiopathic diabetes.
1. Shunt surgery. 2. Bypass duct surgery. 3. Implantation of islets of Langerhans. 4. Repair of congenital anomalies of duodenum, biliary duct system, pancreas will prevent and mitigate the prevalence of diabetes.