A Cross-Sectional Study of Microcirculatory Transit Time as a Risk Stratification Method in Cardiac Syndrome X Conducted in a Tertiary Hospital at Hyderabad, Telangana

Author(s): Krishna Malakondareddy Parvathareddy1, Jagadeesh Reddy Kolli2, Srinivas Ravi3, Praveen Nagula4, Syed Imamuddin5, Venkata Arunavalli Chamarti6

Cardiac syndrome X (CSX) is not benign, and it needs long-term follow up and risk
factor modification. In this study, we wanted to calculate microcirculatory transit
time on coronary angiography in patients with cardiac syndrome X (CSX), compare
microcirculatory transit time in patients with and without CSX and to see whether
microcirculatory transit time can be proposed as a risk stratification method in
Cross sectional study of 52 patients. The angiogram was taken at 15 frames per
second. The left coronary artery was injected with 7 ml of contrast approximately.
Microcirculatory transit time (MCTT) was obtained offline. The microcirculatory
transit time in seconds is calculated as last frame count minus first frame count/15.
Microcirculatory transit time was compared and analysed in both groups.
A total of 52 subjects were analysed. There were 26 cases in the angina group
with a mean age of 49.96 years and 26 cases in the control group with a mean
age of 50.32 years. Dyslipidemia, smoking and statin use were more common in
the angina group, which was statistically significant (P < 0.05). The mean MCTT
of the group with angina and positive treadmill test (TMT) was 6.76 seconds,
whereas the negative TMT group was 6.39 seconds. The mean frame count was
58.1, and the mean MCTT was 3.8 seconds in the control group, whereas the
mean frame count and mean MCTT were 98.1 and 6.5 seconds in the angina
group, which was statistically significant (P < 0.001).
CSX patients had longer MCTT than patients without chest pain and normal
coronary arteries. MCTT can be used to assess the risks of CSX. Long-term followup
studies with a large sample size should be conducted.