Niharika Darasani1
BACKGROUND
Single modality treatment for stage I and stage II squamous cell carcinomas of
glottis region gave excellent results. Since a long time these are treated either
with definitive radiation therapy or surgical excision with endoscopes. There was
not much difference with regard to voice preservation, local recurrence and
disease-free survival period. Our aim was to study the clinical presentation and
management protocol of glottis carcinoma in a tertiary hospital and observe the
final outcome of stage II (T2N0M0) glottis carcinoma and specific factor for
survival in patients treated with surgery, radiotherapy and concurrent
chemoradiation.
METHODS
43 patients of glottis carcinoma stage II (T2N0M0) attending a tertiary teaching
hospital between May 2015 and April 2017 were included in the study.
Demography and smoking status of subjects were recorded. Staging of the disease
was according to American Joint Committee on Cancer (AJCC) Staging System 7th
edition. Paraglottic space infiltration was taken as a criteria to upgrade the staging.
The overall survival rate, recurrence free survival, disease specific survival rate
and laryngeal function preservation rate were calculated.
RESULTS
Out of 43 patients, males were 90.69 % and 09.30 % were females. Male to
female ratio was 10.57 : 1. Mean age was 58.62 ± 2.35 years. 67.44 % were
current smokers, 27.90 % were former smokers and 02.32 % were non-smokers.
The overall survival scores and disease specific survival was 100 % with 11.62 %
locoregional recurrences. The voice preservation was 86.04 %. Radiotherapy was
used in 72.09 %, chemoradiation in 18.60 % patients and 11.62 % patients
underwent surgery. 11.62 % patients presented with locoregional recurrence
during 24 months of follow up. 02.32 % patients had to undergo tracheostomy.
CONCLUSIONS
The overall survival scores and disease specific survival were 100 % with 11.62 %
loco-regional recurrence. Voice preservation was 86.04 %. Proactive prevention
rather than escalation of treatment protocol gives better prognosis.
