Dadichiluka Veeragouri Sankararao1, Kesava Vamsikrishna Bhairavabhatla2
Postoperative Nausea and Vomiting (PONV) is very common in the postoperative period causing discomfort to the patient and also delays discharge. Antiemetic drugs are beneficial for treatment of PONV. We have selected IV metoclopramide (10 mg) and IV ondansetron (4 mg) to compare their efficacy and safety for prophylactic use in postoperative nausea and vomiting in Lower Segment Caesarean Section (LSCS) under spinal anaesthesia.
MATERIALS AND METHODS
We have conducted the study after obtaining the permission from the institutional ethics committee and after obtaining written informed consent in 100 patients aged above 18 years belonging to ASA grade 1 and 2 scheduled to undergo elective LSCS under spinal anaesthesia.
Incidence of nausea was more in group-M than group-O at 2 hours, incidence of vomiting decreased in group-O than group-M and the incidence of retching was reduced significantly in group-O patients at 2 hours.
We conclude from our study that IV ondansetron, a 5HT3 antagonist in the dose of 4 mg has proved as a better prophylactic drug when compared to IV metoclopramide 10 mg in prevention of PONV in LSCS under spinal anaesthesia.