Triveni Ayyanna, Ashok Thaned, Sunil Kasturi
BACKGROUND Cardiovascular diseases (CVD) have been the leading cause of morbidity and mortality in India. Recent trends indicate that the disease is being seen in younger age groups also. It has a significant presence in both males and females, both in urban and rural populations. Acute Coronary Syndromes (ACS) are the major causes of mortality in coronary care units. Inflammation plays an important role in ACS. C-reactive protein is a prototypical acute phase reactant, whose levels are increased proportional to the extent of inflammation. This study is aimed at comparing high sensitivity c-reactive protein levels (hsCRP) with LDL-C/HDLC ratio in patients of acute coronary syndrome. METHODS 100 patients with acute coronary syndrome (STEMI and NSTE-ACS) were included in the study. Serum high sensitivity c-reactive protein levels (hsCRP) and LDL/HDL ratio were measured at admission. Patients were followed up in hospital for mortality and complications. RESULTS There were 76 male and 24 female patients. Mean age for males was 58.73 years and for females was 55.70 years. STEMI was seen in 76 patients and 24 patients had NSTE-ACS. hsCRP were elevated in 68 patients, out of which only 6 patients had LDL/HDL ratio >3 (p <0.01) and among 32 patients in whom hsCRP were not elevated, only 4 patients had LDL/HDL ratio >3. CONCLUSIONS Raised hsCRP level is more significantly associated with the acute coronary syndrome as compared to LDL/HDL ratio. Hence hsCRP levels obtained at admission can be used as a marker for identification of patients who are likely to develop significant complications in the immediate in-hospital course and to predict the prognosis.