Author(s): Durga Prasad Varanasi1, Kailash Prabhudev2
Clonidine, an α2-adrenoreceptor agonist, administered epidurally, is gaining popularity for its analgesic, sympatholytic, hemodynamic stabilizing and sedative properties without significant side effects. METHODS: This present study “A Comparative Study of Epidural Bupivacaine with Clonidine and Epidural Bupivacaine for Post-operative Analgesia” was conducted in 70 cases of ASA grade I and II, between the age groups of 30-75yrs undergoing abdominal, gynecological and orthopedic surgeries under epidural anaesthesia. At the end of surgery, patients were shifted to recovery room. When patients complained of pain with VAS >4/10, they were allocated to receive either of B: Plain Bupivacaine 0.125% 10ml (n = 35). B+C: Clonidine 150 mcg (1ml) + 0.125% Bupivacaine 9ml (n=35). The following parameters were monitored: A. Onset of analgesia. B. Duration of analgesia. C. VAS and Quality of analgesia. D. ardio-respiratory effects: Pulse rate, blood pressure, respiratory rate. E. Side effects like: nausea, vomiting, pruritus, hypotension, sedation and respiratory depression were studied.