Poornima M1, Anjali Siddesh2
OBJECTIVE: To compare the efficacy of mifepristone with misoprostol and misoprostol alone for 2nd trimester termination of pregnancy.
MATERIAL AND METHODS: Total 100 patients admitted in JSS Medical College & Hospital, Mysuru for termination of pregnancy between 13-28 weeks were selected for the study. 50 patient received mifepristone 200 mg orally followed by tab. misoprostol 200mg-400mg per vaginally after 24-36 hours. Vaginal misoprostol repeated 4-6 hourly till pregnancy is terminated other 50 patients received only vaginal misoprostol. The results were analysed
RESULTS: The success rate in both regimens 100%. Induction to abortion interval was shorter in mifepristone with misoprostol group. Mean dose of misoprostol required was around 2.53 (900-1000 microgm) in combined group and 3.44 (1400 microgm) in the misoprostol alone group.
CONCLUSION: pre-treatment with mifepristone 200mg 24 hours before the induction with misoprostol significantly reduce the induction to abortion significantly reduces the induction to abortion interval and reduces the dose and side effects of misoprostol.