Abu Lais Mustaque Ahmed1, Jyotishmoy Bora2
The present work is a prospective clinical study comparing the effects of IV dexmedetomidine and IV Clonidine on attenuation of haemodynamic parameters during laryngoscopy and intubation in patients undergoing elective open cholecystectomy operation under general anaesthesia.
MATERIALS & METHODS
The present study was conducted in the Department of Anaesthesiology of Assam Medical College, Dibrugarh for a period of one year from July 2014 to June 2015 on patients undergoing elective open cholecystectomy at operation theatres of Department of General Surgery of Assam Medical College and Hospital, Dibrugarh. They were divided into two groups with 60 cases in each group by matching patient’s age, sex and ASA grading. Group D-(dexmedetomidine group); in this group patients received 1 mcg/kg dexmedetomidine IV, 15 mins before laryngoscopy and intubation. Group C-(Clonidine group); all the patients in this group received 1 mcg/kg of Clonidine IV, 15 minutes before laryngoscopy and intubation.
The incidence of bradycardia was more in dexmedetomidine group; however, it was not statistically significant. With the present study Inj. dexmedetomidine at a dose of 1 mcg/kg IV was able to prevent adverse haemodynamic changes better than Inj. Clonidine 1 mcg/kg IV prior to laryngoscopy and intubation during elective surgeries under general anaesthesia.
CONCLUSION From the findings of this study, we can come to a conclusion that IV bolus dose of dexmedetomidine 1 mcg/kg administered 15 minutes prior to laryngoscopy and intubation can attenuate the sympathetic response to laryngoscopy and intubation without any major side effects of the drug, in otherwise healthy patients undergoing elective surgeries under general anaesthesia.