Zafer A. Khan1
Dengue is a mosquito-borne viral disease transmitted by Aedes aegypti and Aedes albopictus. It is hypothesised that elevated cytokines such as tumour necrosis factor alpha (TNF-α), interleukins and interferon gamma (IFN-γ) during severe dengue causes damage to the endothelial cells of the capillaries that results in fluid leakage. A novel Extracorporeal Cytokine Adsorption Device (ECAD) CytoSorb® targets the cytokines helps modulate immune response and prevent multiorgan dysfunction syndrome.
MATERIALS AND METHODS
We report a case of dengue fever with septic shock and multiorgan failure admitted in the intensive care. He was treated with standard of care along with mechanical ventilation and renal replacement therapy. A novel ECAD CytoSorb was used as an adjuvant supportive therapy. The patient also received multiple transfusions to address thrombocytopenia and coagulopathy.
The patient showed gradual improvement. The patient showed normalised central nervous system function, improved oxygenation status, adequate renal function and normal platelet count at the time of discharge. The liver function had also improved significantly.
Extracorporeal Cytokine Adsorption device CytoSorb® might be useful option as an adjuvant therapy in dengue patients with MODS.