Philomena James1, Rangaswami Mangalasundaram2, Lavanya Manickam3, Nethaji Sampath4
Tuberous sclerosis is an autosomal dominant disease affecting every generation of the family with widespread manifestation from skin, central nervous system, kidney, heart, etc. Tuberous sclerosis is an extremely heterogeneous disease with wide clinical spectrum varying from severe mental retardation and incapacitating seizures to normal intelligence and lack of seizures, often within the same family. As a general rule, the younger the patient presents with symptoms and signs of Tuberous sclerosis, the greater the likely hood of mental retardation. We here have a case report of a family of tuberous sclerosis with increasing number of cortical tubers and neurological manifestation with each generation of the family.